When you need fast, actionable antibody sequence analysis without the hassle. Antibody-Extractor bypasses time-consuming and tedious antibody sequence analysis steps. Antibody-Extractor™ turns antibody sequence data into information and knowledge. With Antibody-Extractor you industrialize and fast-forward your antibody discovery programs.
AbnomX’s Antibody-Extractor software platform enables researchers to uncover critical and timely antibody insights that reduce development costs and speeds up time to market.
The following chains can readily be processed: Heavy, Kappa, Lambda, Light (Kappa and Lambda mix), VHH (Nanobody). Sequence input accepted: DNA or Protein in fasta or fastq file, single ab1 or multiple ab1 files in compressed zip file. Many organisms are supported: Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Gallus gallus, Camelid. Our developers are ready to add organisms per your requirements.
Process a few or millions of DNA or Protein sequences. Extract, annotate, remove redundancy and cluster the sequences in annotation groups. Identify the sequences corresponding to functional antibodies.
Cluster the sequences according to their encoding V or V-J Genes and performs multiple alignments.
Search for motifs in Frameworks and CDRs.
Compute molecular weight, isoelectric point, extinction coefficient, protease cleavage sites, and much more.
Find highly expressed sequences and how they diverge from their encoding germline genes from NGS runs of millions of sequences.
For rationalization of in-vitro maturation for potency optimization. Perform repertoire mining based on 3D screening of NGS repertoire with a query of antibodies sequences.
Mine immune repertoire for mutations hotspots in V-Region. Discover the amino acids mutated during the somatic hypermutation process.
Machine Learning algorithm to extract germline genes from DNA sequences. Organism and chain agnostic.
Multiple sequence alignment tool based on the 3D structure of immunoglobulin Framework and CDR features.
Screens two datasets for enriched sequence groups.
in-silico cloning tool for batch cloning of VRegions in a vector.
Discover our use cases and the challenges our clients have addressed.
The Antibody-Extractor API framework provides developers with a simple and efficient access to the Antibody-Extractor algorithms and functions. It can also be used as a core package for developing customized immunoinformatics solutions.
If you are interested in getting access to the Antibody-Extractor API please contact firstname.lastname@example.org.
TCR-Profiler is currently under development. It will support researchers to perform sophisticated TCR sequence analyses for all chains, TCRα, TCRβ, TCRg and TCRd, and all three regions, CDR1, CDR2, and CDR3. The software will accept sequence data from a variety of methodologies and workflows.
TCR-Profiler is already used in-house by AbnomX for its own clinical research and for consulting services.